2020-05-01 Example slides
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Inge Wortel
inge.wortel@radboudumc.nl
Department of Tumor Immunology, Radboudumc, Nijmegen, the Netherlands
The Cellular Potts Model (CPM)
Pixels belong to cells, which
move by copying pixels:
Copy success chance (Pcopy) is higher when it helps the cell:
| Stay together: | Maintain its size: | Maintain its membrane: |
| $\searrow$ | $\downarrow$ | $\swarrow$ |
Migration: Act model
Cells move if we add positive feedback on protrusive activity ($\approx$ actin polymerization)1:
| Parameters: | ||
| λact | $\approx$ | protrusive force |
| maxact | $\approx$ | polymerized actin lifetime |
1Niculescu et al. PLoS Computational Biology, 2015.