Supplementary Materials

Interpreting T-cell search “strategies” in the light of evolution under constraints

Simulation S1

Area exploration.
Cellular Potts Model of a migrating cell. Adjust the maxact and λact parameters using the sliders below to change parameters and see the effect on the exploration "fitness". The protrusive front of the cell is colored, and the explored area is shown in gray (for visualization purposes, the shade changes when the cell crosses the periodic border).


Movie S1

Tissue constraints impose different migration patterns in evolved cells with very similar parameters.
Cells migrating in a free environment are broader and move more persistently.